LocationMontreal Heart Institute
Recruitment statusRecruitment complete, follow-up currently in progress
In Canada, there are still important differences in the way men and women are diagnosed and treated for a cardiac disease. Woman, compared to men, tend to be referred for fewer heart tests and procedures, despite a higher mortality rate. One of the reasons for these differences between men and women may be that tests employed to diagnose heart disease in women were originally developed on men and may not apply to women. A new path for improving the cardiac disease evaluation among women may lie in how the inner layer of an individual's coronary artery, called the endothelium, function. Previous research has shown that when a person’s endothelium doesn’t function normally, they are more likely to develop a heart disease. Therefore, the project’s objective is to investigate on how the endothelium’s functioning in both men and women can predict a better or a worse cardiac profile across time.
It is believed that the results of this study will provide data that will inform the choice of diagnostic tests to improve risk stratification and prediction of outcomes in patients, and especially women, at high risk for CVD events.
CIHR-Canadian Institutes of Health Research
- Bacon SL, Lavoie KL, Arsenault A, Dupuis J, Pilote L, Laurin C, Gordon J, Gautrin D, Vadeboncoeur A. (2011). The Research on Endothelial function in Women And men at Risk for cardiovascular Disease (REWARD) Study: Methodology. BMC Cardiovascular Disorders, 11: 50.
- Lavoie KL, Pelletier R, Bacon SL. (2008). Sex differences in traditional and psychological risk factors for cardiovascular disease. In S. Saini (Ed), Anger, Hostility and Aggression – AHA Syndrome: Relationship with Cardiac Diseases and Prevention by Lifestyle Intervention. Anamaya Ltd: India.