LocationMontreal Heart Institute
Using cross-sectional data collected during a standard SPECT exercise test and from an endothelial function study, the current study will assess the mechanistic role of blood pressure and endothelial function in the presentation of silent ischemia. In addition, the current study will track the patients cardiac events over 5-years to assess the longitudinal role ischemia, pain, and endothelial function play in the morbidity and mortality. The aim of this study is to understand why people might not feel any pain when their heart does not get enough blood and how this condition, called silent ischemia, may influence future health. The goals of this study are to better assessing and detailing the pain-blood pressure association in patients undergoing exercise stress testing, to assess the influence of endothelial function on the pain, blood pressure, ischemia relationship; and to explore the long term impact of these factors on patient health.
It is believed that the results of this study will provide data that will inform the choice of diagnostic tests to improve risk stratification and prediction of outcomes in patients, and especially women, at high risk for CVD events.
Michelle Mangal (Research assistant)
Heart and Stroke Foundation
Tomlinson Foundation McGill University
- Mercer DA, Ditto B, Lavoie KL, Campbell T, Arsenault A, Bacon SL. (2018). Health locus of control is associated with physical activity and other health behaviors in cardiac patients. Journal of Cardiopulmonary Rehabilitation and Prevention, 38(6):394-399.
- Stébenne P, Bacon SL, Austin A, Paine NJ, Arsenault A, Laurin C, Meloche B, Gordon J, Dupuis J, Lavoie KL. (2017). Positive and negative affect as related to experiencing chest pain during exercise-induced myocardial ischemia. Psychosomatic Medicine. 79: 395-403
- Moullec G, Plourde A, Lavoie KL, Suarthana E, Bacon SL. (2015). Beck depression inventory II: Determination and comparison of its diagnostic accuracy in cardiac outpatients. European Journal of Preventive Cardiology, 22: 665-672.
- Mercer DA, Lavoie KL, Ditto B, Pelletier R, Campbell T, Arsenault A, Bacon SL. (2014). The interaction between anxiety and depressive symptoms on brachial artery reactivity in cardiac patients. Biological Psychology, 102: 44-50.
- Austin A, Gordon JL, Lavoie KL, Arsenault A, Dasgupta K, Bacon SL. (2014). Differential association of insulin resistance with cognitive and somatic symptoms of depression. Diabetic Medicine, 31: 994-1000.
- Bacon SL, Campbell TS, Arsenault A, Lavoie KL. (2014). The impact of mood and anxiety disorders on incident hypertension at one year. International Journal of Hypertension, 2014: Article ID 953094.
- Rossi A, Davies E, Lavoie KL, Arsenault A, Gordon JL, Meloche B, Bacon SL. (2013). The impact of metabolic syndrome and endothelial dysfunction on exercise-induced cardiovascular changes. Obesity, 12: E143-148.
- Bacon SL, Meloche B, Lavoie KL, Arsenault A. (2012). Differential short-term repeated forearm hyperaemic reactivity in coronary artery disease patients compared to healthy low risk participants. International Journal of Molecular Imaging, 2012: Article ID 578504, 5 pages.
- Gordon J, Lavoie KL, Arsenault A, Meloche B, Ditto B, Campbell TS, Bacon SL. (2012). The relationship between multiple health behaviours and brachial artery reactivity. International Journal of Hypertension, 2012: 846819. doi:10.1155/2012/846819.
- Gordon JL, Lavoie KL, Ditto B, Arsenault A, Bacon SL. (2012). Mood disorders and Cardiovascular Disease. In Juruena M (Ed.), Mood Disorders and Cardiovascular Disease, Clinical, Research and Treatment Approaches to Affective Disorders. Intech: Croatia. Available from: http://www.intechopen.com/articles/show/title/mood-disorders-and-cardiovascular-disease
- Gordon J, Ditto B, Lavoie KL, Pelletier R, Campbell TS, Arsenault A, Bacon SL. (2011). The effect of major depression on post-exercise cardiovascular recovery. Psychophysioloy, 48: 1605-1610.
- Pelletier R, Bacon SL, Laurin C, Arsenault A, Fleet RP, Lavoie KL. (2011). The impact of anxiety disorders on assessment of myocardial ischemia and exercise stress test performance. Journal of Cardiopulmonary Rehabilitation and Prevention, 31: 60-66.
- Pelaez S, Lavoie KL, Gordon J, Arsenault A, Bacon SL. (2010). Social networks and exercise in coronary heart disease patients. Journal of Cardiopulmonary Rehabilitation and Prevention, 30: 324-328.
- Ditto B, Lavoie KL, Campbell TS, Gordon J, Arsenault A, Bacon SL. (2010). Negative association between resting blood pressure and chest pain in people undergoing exercise stress testing for coronary artery disease. Pain, 149: 501-505
- Lavoie KL, Pelletier R, Arsenault A, Dupuis J, Bacon SL. (2010). Association between clinical depression and endothelial function measured by forearm hyperemic reactivity. Psychosomatic Medicine, 72: 20-26
- Pelletier R, Lavoie KL, Gordon J, Arsenault A, Campbell TS, Bacon SL. (2009). The role of mood disorders in exercise-induced cardiovascular reactivity. Psychosomatic Medicine, 71: 301-307.
- Bacon SL, Pelletier R, Lavoie KL. (2009). The impact of acute and chronic exercise on thrombosis in cardiovascular disease. Thrombosis and Haemostasis, 101: 452-459.
- Gordon J, Lavoie KL, Arsenault A, Ditto B, Bacon SL. (2008). Health behaviors and endothelial function. Journal of Behavioral Medicine, 31: 5-21.
- Zhao X, Arsenault A, Lavoie KL, Meloche B, Bacon SL. (2007). Tracer Kinetics of Forearm Endothelial Function: Comparison of an Empirical Method and a Quantitative Modeling Technique. Conference Proceedings IEEE Engineering and Medical Biology Society, 1: 628-31
- Bacon SL, Lavoie KL, Campbell TS, Arsenault A, Ditto B. (2006) Ischemia, pain, and blood pressure response to exercise stress testing. Journal of Human Hypertension, 20: 672-678.
- Arsenault A, Bacon SL, Meloche B. (2005). Reply to: Endothelial function: ready for prime time? Canadian Journal of Cardiology, 21: 796.