This project is complete.


Montreal Heart Institute


Cardiology, Cardiovascular disease


Studies have shown that patients with coronary artery disease (CAD) have higher levels of depression compared to the general population. CAD patients who are depressed may be at higher risk for cardiac events (e.g., myocardial infarction, MI) and mortality compared to CAD patients who are not depressed. However, many of the studies on which these findings are based were conducted in patients right after a major cardiac event (e.g., MI), which makes it difficult to know how much future risk was due to depression and how much future risk was due to the seriousness of the MI. Also, many of these studies only evaluated depressive symptoms, which may not have the same clinical significance as more severe, clinical levels of depression. To resolve these issues, we need to evaluate the impact of clincial depression vs. depressive symptoms on risk for mortality and cardiac events in a sample of stable outpatients who have not just suffered a major cardiac event. To assess the impact of depression level on both the development and progression of CAD, it would be useful to study a sample of patients with and without known CAD. That is the main purpose of the DECADE study.