LocationHôpital du Sacré-Cœur de Montréal
Recruitment statusRecruitment complete, follow-up currently in progress
Uncontrolled asthma is the #1 cause of asthma-related mortality, which claims the lives of nearly 450 Canadians per year. Achieving optimal asthma control relies upon several behavioral factors (e.g., self-monitoring, treatment adherence) that may be influenced by chronic negative mood states and anxiety disorders. Those disorders may influence asthma outcomes by altering the way patients cognitively interpret and behave towards their disease, and may result in poor self-management and worse levels of asthma control. Though previous studies have reported associations between mood and anxiety disorders and worse asthma control and/or asthma-related quality of life, no studies to date that have assessed the extent to which mood and anxiety disorders are predictive of worse asthma control and quality of life.
As such, the present proposal has two main objectives: to examine the extent to which mood and/or anxiety disorders are independent risk factors for worse asthma control and quality of life; and to assess the cognitive (e.g., illness perceptions) and behavioral (e.g., treatment adherence) mechanisms by which this may occur.
This study is the first to establish whether mood and/or anxiety disorders are independent risk factors for worse asthma control and quality of life, and by what cognitive and behavioral mechanisms this may occur. The results may be used to inform physicians about the importance of considering psychological and behavioral risk factors for chronic disease and inform the development and implementation of interventions designed to treat psychiatric disorders and improve asthma outcomes in high-risk patients.
Conseil de recherches en sciences humaines
Fondation Michel Auger
Fonds de la recherche en santé du Québec (FRSQ)
1. Wright A, Lavoie KL, Jacob A, Rizk A, Bacon SL. Effects of body mass index on exercise as a reported asthma trigger. The Physician and Sportsmedicine 2010, 38:61-6.
2. Bacon SL, Bouchard A, Loucks E, Lavoie KL*. Is socio-economic status associated with worse asthma morbidity in a Canadian sample of adult asthmatics? Respiratory Research 2009;10:125.
3. Lavoie KL, Bouchard A, Joseph M, Campbell TS, Favreau H, Bacon SL. Association of asthma self-efficacy to asthma control and quality of life. Ann Behav Med 2008 ;36:100-6.
4. Barone S, Labrecque M, Campbell TS, Ditto B, Bacon SL, Lavoie KL*. The association between atopy and anxiety sensitivity in adult asthmatics. J Behav Med 2008;31:331-339.
5. Bacon SL, Bergeron C, Boulet LP, Chen Y, Dixon A, Ernst P, Hamid Q, Holguin F, Irvin CG, Kimoff RJ, Komakuloff S, Laprise C, Lavoie KL, Shore S, Theodorescu M, Vohl MC. Symposium on obesity and asthma: November 2006. Can Respir J 2007; 14:201-8.
6. Lavoie KL, Bacon SL, Cartier A, Barone S, Ditto B, Labrecque M. What’s worse for asthma: mood disorders, anxiety disorders, or both? CHEST 2006; 130:1039-1047.
7. Lavoie KL, Bacon SL, Labrecque M, Cartier A, Ditto B. Higher body mass index is associated with worse asthma control and quality of life among adult asthma patients. Respir Med 2006; 100: 648–657.
8. Lavoie KL, Cartier A, Labrecque M, Bacon SL, Lacoste G, Barone S, Verrier P, Ditto B. Are psychiatric disorders associated with worse asthma control and quality of life in asthma patients? Respir Med 2005; 99; 1249-1257.