• MBMC Completed projects

The impact of daily psychological stress at work on occupational asthma and work related asthma (SPEAR)

Hôpital du Sacré-Cœur de Montréal

This study aimed to assess how psychological stress impacts the experience asthma symptoms (e.g., breathlessness, cough) and lung function (e.g., daily variability of peak flow) in the workplace and to identify the physiological mechanisms underlying this association.

Category: Respiratory

Funding/Sponsors:

Asthma in the Workplace Centre, Canadian Institutes of Health Research (CIHR)

Selected publications:

Coming soon

Impact of anxiety on respiratory responses in asthmatics (SPIRALE)

Hôpital du Sacré-Cœur de Montréal

The results from this study could help direct treatment resources for asthmatics who may be at greater risk for asthma exacerbation and morbidity (and suffer a significantly reduced quality of life) as a result of their response to stress.

Category: Respiratory

Funding/Sponsors:

Canadian Institutes of Health Research (CIHR)
Fonds de recherche en santé du Québec (FRQ-S)

Selected publications:

- Boudreau M, Bacon SL, Paine NJ, Cartier A, Trutschnigg B, Morizio A, Lavoie KL. (In Press). Impact of panic attacks on bronchoconstriction and subjective distress in asthma patients with and without panic disorder. Psychosomatic Medicine.

- Boudreau M, Lavoie KL, Cartier A, Trutshnigg B, Morizio A, Lemière C, Bacon SL. (2015) Do asthma patients with panic disorder really have worse asthma? A comparison of physiological and psychological responses to a methacholine challenge. Respiratory Medicine, 109(10):1250-6.

Behavioural weight management as a treatment for asthma (pilot study) (BEAT-Asthma)

Hôpital du Sacré-Cœur de Montréal

The current pilot project aims to generate data on the level of change that could be observed, following a behavioral weight control program, in the control of asthma symptoms (e.g., taking medication) and the quality of life in overweight asthmatic patients.

Category: Asthma, Respiratory

Funding/Sponsors:

Concordia University Pilot Grant

Selected publications:

- Jacob, A., Lavoie, K.L., Bacon, S.L. (2015). The impact of a cognitive-behavioral (CBT) weight management program on weight change and depressive symptoms in asthmatic patients: A pilot study. Canadian Psychology Annual Convention Issue, 56(2a) 141.

Effects of aerobic exercise on asthma (EX-ASTHMA)

Hôpital du Sacré-Cœur de Montréal

The current study is designed to assess the efficacy of aerobic exercise as an intervention to improve asthma control and quality of life in adult patients with asthma, and explore the potential mechanisms behind the expected improvements.

Category: Asthma, Respiratory

Funding/Sponsors:

Conseil de recherches en sciences humaines (CRSH)
Fonds de la recherche en santé du Québec (FRSQ)

Selected publications:

- Bacon SL, Lavoie KL, Bourbeau J, Ernst P, Maghni K, Gautrin D, Labrecque M, Pepin V, Pedersen BK. (2013). The effects of a multi-site aerobic exercise intervention on asthma morbidity in sedentary adults with asthma: The ex-asthma study randomised controlled trial protocol. BMJ Open, 3: e003177.

Mechanisms Outcomes of Silent Myocardial Ischemia (MOSMI)

Montreal Heart Institute

The aim of this study is to understand why people might not feel any pain when their heart does not get enough blood and how this condition, called silent ischemia, may influence future health.

Category: Cardiology

Funding/Sponsors:

Heart and Stroke Foundation
Tomlinson Foundation McGill University

Selected publications:

- Stébenne P, Bacon SL, Austin A, Paine NJ, Arsenault A, Laurin C, Meloche B, Gordon J, Dupuis J, Lavoie KL. (2017). Positive and negative affect as related to experiencing chest pain during exercise-induced myocardial ischemia. Psychosomatic Medicine. 79: 395-403

- Moullec G, Plourde A, Lavoie KL, Suarthana E, Bacon SL. (2015). Beck depression inventory II: Determination and comparison of its diagnostic accuracy in cardiac outpatients. European Journal of Preventive Cardiology, 22: 665-672.

- Mercer DA, Lavoie KL, Ditto B, Pelletier R, Campbell T, Arsenault A, Bacon SL. (2014). The interaction between anxiety and depressive symptoms on brachial artery reactivity in cardiac patients. Biological Psychology, 102: 44-50.

- Austin A, Gordon JL, Lavoie KL, Arsenault A, Dasgupta K, Bacon SL. (2014). Differential association of insulin resistance with cognitive and somatic symptoms of depression. Diabetic Medicine, 31: 994-1000.

- Bacon SL, Campbell TS, Arsenault A, Lavoie KL. (2014). The impact of mood and anxiety disorders on incident hypertension at one year. International Journal of Hypertension, 2014: Article ID 953094.

- Rossi A, Davies E, Lavoie KL, Arsenault A, Gordon JL, Meloche B, Bacon SL. (2013). The impact of metabolic syndrome and endothelial dysfunction on exercise-induced cardiovascular changes. Obesity, 12: E143-148.

- Bacon SL, Meloche B, Lavoie KL, Arsenault A. (2012). Differential short-term repeated forearm hyperaemic reactivity in coronary artery disease patients compared to healthy low risk participants. International Journal of Molecular Imaging, 2012: Article ID 578504, 5 pages.

- Gordon J, Lavoie KL, Arsenault A, Meloche B, Ditto B, Campbell TS, Bacon SL. (2012). The relationship between multiple health behaviours and brachial artery reactivity. International Journal of Hypertension, 2012: 846819. doi:10.1155/2012/846819.

- Gordon JL, Lavoie KL, Ditto B, Arsenault A, Bacon SL. (2012). Mood disorders and Cardiovascular Disease. In Juruena M (Ed.), Mood Disorders and Cardiovascular Disease, Clinical, Research and Treatment Approaches to Affective Disorders. Intech: Croatia. Available from: http://www.intechopen.com/articles/show/title/mood-disorders-and-cardiovascular-disease

- Gordon J, Ditto B, Lavoie KL, Pelletier R, Campbell TS, Arsenault A, Bacon SL. (2011). The effect of major depression on post-exercise cardiovascular recovery. Psychophysioloy, 48: 1605-1610.

- Pelletier R, Bacon SL, Laurin C, Arsenault A, Fleet RP, Lavoie KL. (2011). The impact of anxiety disorders on assessment of myocardial ischemia and exercise stress test performance. Journal of Cardiopulmonary Rehabilitation and Prevention, 31: 60-66.

- Pelaez S, Lavoie KL, Gordon J, Arsenault A, Bacon SL. (2010). Social networks and exercise in coronary heart disease patients. Journal of Cardiopulmonary Rehabilitation and Prevention, 30: 324-328.

- Ditto B, Lavoie KL, Campbell TS, Gordon J, Arsenault A, Bacon SL. (2010). Negative association between resting blood pressure and chest pain in people undergoing exercise stress testing for coronary artery disease. Pain, 149: 501-505

- Lavoie KL, Pelletier R, Arsenault A, Dupuis J, Bacon SL. (2010). Association between clinical depression and endothelial function measured by forearm hyperemic reactivity. Psychosomatic Medicine, 72: 20-26

- Pelletier R, Lavoie KL, Gordon J, Arsenault A, Campbell TS, Bacon SL. (2009). The role of mood disorders in exercise-induced cardiovascular reactivity. Psychosomatic Medicine, 71: 301-307.

- Bacon SL, Pelletier R, Lavoie KL. (2009). The impact of acute and chronic exercise on thrombosis in cardiovascular disease. Thrombosis and Haemostasis, 101: 452-459.

- Gordon J, Lavoie KL, Arsenault A, Ditto B, Bacon SL. (2008). Health behaviors and endothelial function. Journal of Behavioral Medicine, 31: 5-21.

- Zhao X, Arsenault A, Lavoie KL, Meloche B, Bacon SL. (2007). Tracer Kinetics of Forearm Endothelial Function: Comparison of an Empirical Method and a Quantitative Modeling Technique. Conference Proceedings IEEE Engineering and Medical Biology Society, 1: 628-31

- Bacon SL, Lavoie KL, Campbell TS, Arsenault A, Ditto B. (2006) Ischemia, pain, and blood pressure response to exercise stress testing. Journal of Human Hypertension, 20: 672-678.

- Arsenault A, Bacon SL, Meloche B. (2005). Reply to: Endothelial function: ready for prime time? Canadian Journal of Cardiology, 21: 796.

Impact of psychiatric disorders on asthma and occupational outcomes in patients under investigation for occupational asthma (OASIS)

Hôpital du Sacré-Cœur de Montréal

Contribute to determining the extent to which varying degrees of psychological stress (from moderately elevated scores on measures of anxiety and depression to meeting diagnostic criteria for a clinically significant psychiatric disorder) can negatively impact occupational, health and quality of life outcomes in patients who present with asthma-like symptoms in the workplace.

Category: Respiratory

Funding/Sponsors:

IRSST- Institut de Recherche en Santé et Sécurité au Travail
Asthma in the Workplace Centre
Canadian Institutes of Health Research (CIHR)

Selected publications:

- Lavoie KL, Favreau H, Paine NJ, Lemiere C, Joseph M, Gagnon-Chauvin A, Cartier A, Bacon SL. (2016). Prospective impact of psychiatric disorders on employment status and healthcare use in patients investigated for occupational asthma. Journal of Occupational and Environmental Medicine, 58: 1196-1201.

- Lavoie KL. (2014). Prévalence du stress psychologiques et des troubles psychiatriques chez les patients soumis à une évaluation relative à l’asthme professionnel et l’impact sur la situation d’emploi et l’utilisation des services de la santé au terme de suivi de 12 à 18 mois IRRST Rapports scientifiques, septembre 2014.

- Lavoie KL, Joseph M, Favreau H, Lemiere C, Labrecque M, Cartier A, Malo J-L, Gautrin D, Bacon SL. (2013). Prevalence of psychiatric disorders among patients investigated for occupational asthma: An overlooked differential diagnosis? American Journal of Respiratory and Critical Care Medicine, 187: 926-932.

- Malo JL, Lemiére C, Gautrin D, Lavoie KL, Labrecque M. (2010). Asthma and the Workplace
In : Asthma, Health, and Society : From the Clinic to the Public, Andrew Harver & Harry Kotses, (Eds). Springer.

- Lavoie KL, Joseph M, Bacon SL. (2009). Psychosocial factors and occupational asthma. Current Opinion in Asthma and Clinical Immunology, 9:103-9.

- Yacoub MR, Lavoie KL, Guillaume L, Daigle S, L’Archevêque J, Ghezzo H, Lemière C, Malo JL. (2007). Assessment of impairment/disability due to occupational asthma through a multidimensional approach. Eur Respir J; 29:889-96.

- Tarlo S, Malo JL. (2009). Third Jack Pepys Workshop on Asthma in the Workplace Participants. An official ATS proceedings: asthma in the workplace: the Third Jack Pepys Workshop on Asthma in the Workplace: answered and unanswered questions. Proc Am Thorac Soc. 2009 Aug 1;6(4):339-49.

- Tarlo, SM, Malo, JL, and Workshop Members (2006). Perspective: An American Thoracic Society/European Thoracic Society Report. 100 key questions and needs in occupational asthma. Eur Respir J; 27: 607–614.

Depression effects on coronary artery disease events (DECADE)

Montreal Heart Institute

The main purpose of the DECADE study is to study a sample of patients with and without known coronary artery disease (CAD) in order to assess the impact of depression level on both the development and progression of CAD.

Category: Cardiology, Cardiovascular disease

Funding/Sponsors:

Heart and Stroke Foundation of Quebec

Selected publications:

- Paine NJ, Bacon SL, Pelletier R, Arsenault A, Diodati JG, Lavoie KL. (2016). Do women with anxiety or depression have higher rates of myocardial ischemia during exercise testing than men? Circulation: Cardiovascular Quality and Outcomes, 9: S53-61.

- Pelletier R, Bacon SL, Arsenault A, Dupuis J, Laurin C, Blais L, Lavoie KL. (2015). The Relative Associations between Depression and Anxiety on Adverse Cardiovascular Events: Does a History of Coronary Artery Disease Matter? A Prospective Observational Study. BMJ Open, 5: e006582.

- Lavoie KL, Fleet PP, Lesperance F, Laurin C, Arsenault A, Frasure-Smith N, Burelle D, Bacon SL. (2004). Are exercise stress tests appropriate for assessing myocardial ischemia in patients with major depressive disorder? American Heart Journal, 148: 621-627.

- Lavoie KL, Fleet RP, Laurin C, Arsenault A, Miller SB, Bacon SL. (2004). Heart rate variability in coronary artery disease patients with and without panic disorder. Psychiatry Research, 128: 289-299.