• MBMC Completed projects

Mechanisms Outcomes of Silent Myocardial Ischemia (MOSMI)

Montreal Heart Institute

The aim of this study is to understand why people might not feel any pain when their heart does not get enough blood and how this condition, called silent ischemia, may influence future health.

Category: Cardiology

Funding/Sponsors:

Heart and Stroke Foundation
Tomlinson Foundation McGill University

Selected publications:

Coming soon

The impact of daily psychological stress at work on occupational asthma and work related asthma (SPEAR)

Hôpital du Sacré-Cœur de Montréal

This study aimed to assess how psychological stress impacts the experience asthma symptoms (e.g., breathlessness, cough) and lung function (e.g., daily variability of peak flow) in the workplace and to identify the physiological mechanisms underlying this association.

Category: Respiratory

Funding/Sponsors:

Asthma in the Workplace Centre, Canadian Institutes of Health Research (CIHR)

Selected publications:

Coming soon

Depression effects on coronary artery disease events (DECADE)

Montreal Heart Institute

The main purpose of the DECADE study is to study a sample of patients with and without known coronary artery disease (CAD) in order to assess the impact of depression level on both the development and progression of CAD.

Category: Cardiology, Cardiovascular disease

Funding/Sponsors:

Heart and Stroke Foundation of Quebec

Selected publications:

Lavoie KL, Pelletier R, Arsenault A, Dupuis J, Bacon SL. Impact of depression and coronary heart disease status on endothelial function measured by forearm hyperemic reactivity. Psychosomatic Medicine 2010 72:20-26.
Pelletier R, Bacon SL, Arsenault A, Campbell TS, Fleet RP, Lavoie KL. The impact of anxiety disorders and electrocardiographic assessment of myocardial ischemia and exercise stress test performance. Journal of Cardiopulmonary Rehabilitation 2011 31(1):60-6.
Pelletier R, Lavoie KL, Gordon J, Arsenault A, Campbell TS, Bacon SL. The role of mood disorders in exercise-induced cardiovascular reactivity. Psychosom Med 2009, 71:301-7.
Lavoie KL, Pelletier R, Bacon SL. Sex differences in traditional and psychological risk factors for cardiovascular disease. In S. Saini (Ed), Anger, Hostility and Aggression – AHA Syndrome: Relationship with Cardiac Diseases and Prevention by Lifestyle Intervention, ANAMAYA Publication, Ltd. India, 2008.

Impact of psychiatric disorders on asthma and occupational outcomes in patients under investigation for occupational asthma (OASIS)

Hôpital du Sacré-Cœur de Montréal

Contribute to determining the extent to which varying degrees of psychological stress (from moderately elevated scores on measures of anxiety and depression to meeting diagnostic criteria for a clinically significant psychiatric disorder) can negatively impact occupational, health and quality of life outcomes in patients who present with asthma-like symptoms in the workplace.

Category: Respiratory

Funding/Sponsors:

IRSST- Institut de Recherche en Santé et Sécurité au Travail
Asthma in the Workplace Centre
Canadian Institutes of Health Research (CIHR)

Selected publications:

1. Lavoie KL, Joseph M, Bacon SL. Psychosocial factors and occupational asthma. Current Opinion in Asthma and Clinical Immunology 2009, 9:103-9.
2. Yacoub MR, Lavoie KL, Guillaume L, Daigle S, L’Archevêque J, Ghezzo H, Lemière C, Malo JL. Assessment of impairment/disability due to occupational asthma through a multidimensional approach. Eur Respir J 2007; 29:889-96.
3. Malo JL, Lemiére C, Gautrin D, Lavoie KL, Labrecque M. Asthma and the Workplace
In : Asthma, Health, and Society : From the Clinic to the Public, Andrew Harver & Harry Kotses, (Eds). Springer. 2010.
4. Tarlo S, Malo JL, Third Jack Pepys Workshop on Asthma in the Workplace Participants. An official ATS proceedings: asthma in the workplace: the Third Jack Pepys Workshop on Asthma in the Workplace: answered and unanswered questions. Proc Am Thorac Soc. 2009 Aug 1;6(4):339-49.
5. Tarlo, SM, Malo, JL, and Workshop Members. Perspective: An American Thoracic Society/European Thoracic Society Report. 100 key questions and needs in occupational asthma. Eur Respir J 2006; 27: 607–614.

Behavioural weight management as a treatment for asthma (pilot study) (BEAT-Asthma)

Hôpital du Sacré-Cœur de Montréal

The current pilot project aims to generate data on the level of change that could be observed, following a behavioral weight control program, in the control of asthma symptoms (e.g., taking medication) and the quality of life in overweight asthmatic patients.

Category: Asthma, Respiratory

Funding/Sponsors:

Concordia University Pilot Grant

Selected publications:

Jacob, A., Lavoie, K.L., Bacon, S.L. (2015). The impact of a cognitive-behavioral (CBT) weight management program on weight change and depressive symptoms in asthmatic patients: A pilot study. Canadian Psychology Annual Convention Issue, 56(2a) 141.

Impact of anxiety on respiratory responses in asthmatics (SPIRALE)

Hôpital du Sacré-Cœur de Montréal

The results from this study could help direct treatment resources for asthmatics who may be at greater risk for asthma exacerbation and morbidity (and suffer a significantly reduced quality of life) as a result of their response to stress.

Category: Respiratory

Funding/Sponsors:

Canadian Institutes of Health Research (CIHR)
Fonds de recherche en santé du Québec (FRQ-S)

Selected publications:

1. Boudreau M, Lavoie KL, Cartier A, Trutshnigg B, Morizio A, Lemière C, Bacon SL. Do asthma patients with panic disorder really have worse asthma? A comparison of physiological and psychological responses to a methacholine challenge. Respiratory Medicine 2015 Oct;109(10):1250-6.

Effects of aerobic exercise on asthma (EX-ASTHMA)

Hôpital du Sacré-Cœur de Montréal

The current study is designed to assess the efficacy of aerobic exercise as an intervention to improve asthma control and quality of life in adult patients with asthma, and explore the potential mechanisms behind the expected improvements.

Category: Asthma, Respiratory

Funding/Sponsors:

Conseil de recherches en sciences humaines (CRSH)
Fonds de la recherche en santé du Québec (FRSQ)

Selected publications:

1. Bacon SL, Lavoie KL, Bourbeau J, Ernst P, Maghni K, Gautrin D, Labrecque M, Pepin V, Pedersen BK. (2013). The effects of a multi-site aerobic exercise intervention on asthma morbidity in sedentary adults with asthma: The ex-asthma study randomised controlled trial protocol. BMJ Open, 3: e003177.)